Anti-IRS2 Polyclonal Antibody (HV817014)

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规格：

50ug
100ug

数量：

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概述
图片
参考文献
产品说明书

HV817014

abinScience

种属反应性

Human, Mouse

ELISA, IHC, WB

Rabbit

Polyclonal

E. coli - derived recombinant Human IRS2 (Gly185-Arg301).

IRS2, Insulin receptor substrate 2, IRS-2

Purified by antigen affinity column.

Accession号

Q9Y4H2

Liquid

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Insulin receptor substrate 2 (IRS2) is a ~137 kDa protein. Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R. Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism. Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2. Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade. Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation.

1. Fukushima, T. et al. (2015) Nature communications 6, 6780. PMID: 25879670

2. Geng, Y. et al. (2014) The Journal of biological chemistry 289, 11230-11241. PMID: 24616100

3. Duan, C. et al. (2004) The Journal of biological chemistry 279, 43684-91. PMID: 15316008

4. Heller, NM. et al. (2008) Science signaling 1, ra17. PMID: 19109239

5. Manohar, S. et al. (2020) Molecular & cellular proteomics : MCP 19, 1450-1467. PMID: 32554797

For research use only.

产品说明书

Anti-IRS2 Polyclonal Antibody.pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-IRS2 Polyclonal Antibody (HV817014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-IRS2 Polyclonal Antibody (HV817014)

概述

图片

参考文献

产品说明书

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