

| 货号 | HP219014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 品牌 | abinScience | ||||||||
| 种属反应性 | Human | ||||||||
| 应用 | ELISA, IHC, WB | ||||||||
| 宿主 | Rabbit | ||||||||
| 克隆类型 | Polyclonal | ||||||||
| 同种型 | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human TMEM165 (Gly34-Thr89). | ||||||||
| 靶标 | TPARL, TMEM165, Transmembrane protein PT27, Transmembrane protein TPARL, Transmembrane protein 165 | ||||||||
| 纯化方式 | Purified by antigen affinity column. | ||||||||
| Accession号 | Q9HC07 | ||||||||
| 状态 | Liquid | ||||||||
| 保存溶液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| 产品使用信息 |
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| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Putative divalent cation/proton antiporter TMEM165 is a ~34 kDa protein. Putative divalent cation:proton antiporter that exchanges calcium or manganese ions for protons across the Golgi membrane. Mediates the reversible transport of calcium or manganese to the Golgi lumen driven by the proton gradient and possibly the membrane potential generated by V-ATPase. Provides calcium or manganese cofactors to resident Golgi enzymes and contributes to the maintenance of an acidic luminal Golgi pH required for proper functioning of the secretory pathway. Promotes Ca(2+) storage within the Golgi lumen of the mammary epithelial cells to be then secreted into milk. The transport mechanism and stoichiometry remains to be elucidated. 1. Foulquier, F. et al. (2012) American journal of human genetics 91, 15-26. PMID: 22683087 2. Demaegd, D. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 6859-64. PMID: 23569283 3. Potelle, S. et al. (2016) Human molecular genetics 25, 1489-500. PMID: 27008884 4. Stribny, J. et al. (2020) The Journal of biological chemistry 295, 3865-3874. PMID: 32047108 | ||||||||
| Note | For research use only. |

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