

| 货号 | HP973014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 品牌 | abinScience | ||||||||
| 种属反应性 | Human | ||||||||
| 应用 | ELISA, IHC, WB | ||||||||
| 宿主 | Rabbit | ||||||||
| 克隆类型 | Polyclonal | ||||||||
| 同种型 | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ALKBH7 (Ser16-Cys221). | ||||||||
| 靶标 | Spermatogenesis-associated protein 11, ABH7, Alkylated DNA repair protein alkB homolog 7, ALKBH7, Spermatogenesis cell proliferation-related protein, SPATA11, Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial | ||||||||
| 纯化方式 | Purified by antigen affinity column. | ||||||||
| Accession号 | Q9BT30 | ||||||||
| 状态 | Liquid | ||||||||
| 保存溶液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| 产品使用信息 |
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| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | RNA demethylase ALKBH7, mitochondrial is a ~24 kDa protein. RNA demethylase that demethylates N(2)-dimethylguanosine and N(1)-methyladenosine within mitochondrial pre-tRNA regions. This demethylation activity plays a crucial role in regulating the processing of nascent polycistronic mitochondrial RNA, thereby influencing mitochondrial gene expression and overall mitochondrial activity. In response to extensive DNA damage is required for programmed necrosis induced by alkylation and oxidation. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death. Involved in fatty acid metabolism. 1. Zhang, LS. et al. (2021) Nature cell biology 23, 684-691. PMID: 34253897 2. Fu, D. et al. (2013) Genes & development 27, 1089-100. PMID: 23666923 | ||||||||
| Note | For research use only. |

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