Anti-Human APH1A Polyclonal Antibody (HP487014)

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50ug
100ug

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概述
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参考文献
产品说明书

HP487014

abinScience

种属反应性

Human, Mouse

ELISA, IHC, WB

Rabbit

Polyclonal

E. coli - derived recombinant Human APH1A (Asn207-Asp265).

Gamma-secretase subunit APH-1A, PSF, Presenilin-stabilization factor, APH-1a, APH1A, Aph-1alpha

Purified by antigen affinity column.

Accession号

Q96BI3

Liquid

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Gamma-secretase subunit APH-1A (APH1A) is a ~28 kDa protein. Non-catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Required for normal gamma-secretase assembly. The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable).

1. Lee, SF. et al. (2002) The Journal of biological chemistry 277, 45013-9. PMID: 12297508

2. Luo, WJ. et al. (2003) The Journal of biological chemistry 278, 7850-4. PMID: 12522139

3. Edbauer, D. et al. (2003) Nature cell biology 5, 486-8. PMID: 12679784

4. Marlow, L. et al. (2003) Biochemical and biophysical research communications 305, 502-9. PMID: 12763021

5. Lu, P. et al. (2014) Nature 512, 166-170. PMID: 25043039

6. Bai, XC. et al. (2015) Nature 525, 212-217. PMID: 26280335

7. Yang, G. et al. (2019) Nature 565, 192-197. PMID: 30598546

8. Zhou, R. et al. (2019) Science (New York, N.Y.) 363. PMID: 30630874

9. Gu, Y. et al. (2003) The Journal of biological chemistry 278, 7374-80. PMID: 12471034

For research use only.

产品说明书

Anti-Human APH1A Polyclonal Antibody.pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human APH1A Polyclonal Antibody (HP487014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human APH1A Polyclonal Antibody (HP487014)

概述

图片

参考文献

产品说明书

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