| 背景 | Platelet glycoprotein 4 (CD36) is a ~52 kDa protein. Multifunctional glycoprotein that acts as a receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. The dependency on coreceptor signaling is strongly ligand specific. Cellular responses to these ligands are involved in angiogenesis, inflammatory response, fatty acid metabolism, taste and dietary fat processing in the intestine (Probable). 1. Endemann, G. et al. (1993) The Journal of biological chemistry 268, 11811-6. PMID: 76850212. Jimenez-Dalmaroni, MJ. et al. (2009) PloS one 4, e7411. PMID: 198472893. Stewart, CR. et al. (2010) Nature immunology 11, 155-61. PMID: 200375844. Heit, B. et al. (2013) Developmental cell 24, 372-83. PMID: 233953926. Hao, JW. et al. (2020) Nature communications 11, 4765. PMID: 329587807. Nassir, F. et al. (2007) The Journal of biological chemistry 282, 19493-501. PMID: 175073718. Masuda, D. et al. (2009) Journal of lipid research 50, 999-1011. PMID: 187536759. Tran, TT. et al. (2011) The Journal of biological chemistry 286, 25201-10. PMID: 2161006910. Laugerette, F. et al. (2005) The Journal of clinical investigation 115, 3177-84. PMID: 16276419 |
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