Anti-Mouse ASAH2 Polyclonal Antibody (MP220014)

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50ug
100ug

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概述
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参考文献
产品说明书

MP220014

abinScience

种属反应性

Mouse

ELISA, IHC, WB

Rabbit

Polyclonal

E. coli - derived recombinant Mouse ASAH2 (Glu641-Thr756).

Neutral ceramidase (N-CDase) (NCDase) (EC 3.5.1.-) (EC 3.5.1.23) (Acylsphingosine deacylase 2) (N-acylsphingosine amidohydrolase 2) [Cleaved into: Neutral ceramidase soluble form]

Purified by antigen affinity column.

Accession号

Q9JHE3

Liquid

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Neutral ceramidase (ASAH2) is a ~83 kDa protein. Plasma membrane ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at neutral pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine. Together with sphingomyelinase, participates in the production of sphingosine and sphingosine-1-phosphate from the degradation of sphingomyelin, a sphingolipid enriched in the plasma membrane of cells. Also participates in the hydrolysis of ceramides from the extracellular milieu allowing the production of sphingosine-1-phosphate inside and outside cells.

1. Tani, M. et al. (2000) The Journal of biological chemistry 275, 3462-8. PMID: 10652340

2. Tani, M. et al. (2000) The Journal of biological chemistry 275, 11229-34. PMID: 10753931

3. Kono, M. et al. (2006) The Journal of biological chemistry 281, 7324-31. PMID: 16380386

4. Choi, MS. et al. (2003) Gene 315, 113-22. PMID: 14557071

5. Novgorodov, SA. et al. (2011) The Journal of biological chemistry 286, 25352-62. PMID: 21613224

6. Tani, M. et al. (2005) The Journal of biological chemistry 280, 36592-600. PMID: 16126722

For research use only.

产品说明书

Anti-Mouse ASAH2 Polyclonal Antibody.pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

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试剂盒

实验相关试剂

Anti-Mouse ASAH2 Polyclonal Antibody (MP220014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Mouse ASAH2 Polyclonal Antibody (MP220014)

概述

图片

参考文献

产品说明书

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