Anti-Human ADGRG3 Polyclonal Antibody (HA966014)

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100ug

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概述
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参考文献
产品说明书

概述

货号

HA966014

品牌

abinScience

描述

Anti-Human ADGRG3 Polyclonal Antibody (HA966014) is a rabbit polyclonal antibody detecting ADGRG3 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human ADGRG3 (Gln21-Ser272).

靶标

ADGRG3, PGR26, G-protein coupled receptor 97, Adhesion G protein-coupled receptor G3, GPR97, G-protein coupled receptor PGR26

纯化方式

Purified by antigen affinity column.

Accession号

Q86Y34

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Adhesion G protein-coupled receptor G3 (ADGRG3) is a ~60 kDa protein. Adhesion G-protein coupled receptor (aGPCR) for glucocorticoid hormones such as cortisol, cortisone and 11-deoxycortisol. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. ADGRG3/GPR97 is coupled to G(o)/GNAO1 G proteins and mediates signaling by inhibiting adenylate cyclase activity. May also signal through G-alpha(q)-proteins; additional evidence are however required to confirm this result in vivo. Plays a role in the regulation of various processes including B-cell development, inflammation or innate immunity.

1. Ping, YQ. et al. (2021) Nature 589, 620-626. PMID: 33408414

2. Gupte, J. et al. (2012) FEBS letters 586, 1214-9. PMID: 22575658

3. Hsiao, CC. et al. (2018) Frontiers in immunology 9, 2830. PMID: 30559745

4. Chu, TY. et al. (2022) Nature communications 13, 6385. PMID: 36302784

5. Valtcheva, N. et al. (2013) The Journal of biological chemistry 288, 35736-48. PMID: 24178298

Note

For research use only.

图片

参考文献

产品说明书

Anti-Human ADGRG3 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human ADGRG3 Polyclonal Antibody (HA966014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human ADGRG3 Polyclonal Antibody (HA966014)

概述

图片

参考文献

产品说明书

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