Anti-Human WRAP53 Polyclonal Antibody (HA912014)

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概述
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参考文献
产品说明书

概述

货号

HA912014

品牌

abinScience

描述

Anti-Human WRAP53 Polyclonal Antibody (HA912014) is a rabbit polyclonal antibody detecting WRAP53 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Human, Mouse, Rat

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human WRAP53 (Ser165-Tyr418).

靶标

WD repeat-containing protein 79, TCAB1, WD40 repeat-containing protein antisense to TP53 gene, Telomerase Cajal body protein 1, WRAP53, WRAP53beta, WDR79

纯化方式

Purified by antigen affinity column.

Accession号

Q9BUR4

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Telomerase Cajal body protein 1 (WRAP53) is a ~59 kDa protein. RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies. Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes. In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex. Acts by specifically binding the CAB box of the TERC RNA and controlling the folding of the CR4/CR5 region of the TERC RNA, a critical step for telomerase activity.

1. Nguyen, THD. et al. (2018) Nature 557, 190-195. PMID: 29695869

2. Chen, L. et al. (2018) Cell 174, 218-230.e13. PMID: 29804836

3. Tycowski, KT. et al. (2009) Molecular cell 34, 47-57. PMID: 19285445

4. Egan, ED. et al. (2010) Molecular and cellular biology 30, 2775-86. PMID: 20351177

5. Venteicher, AS. et al. (2009) Science (New York, N.Y.) 323, 644-8. PMID: 19179534

6. Vogan, JM. et al. (2015) The Journal of biological chemistry 290, 21320-35. PMID: 26170453

Note

For research use only.

图片

参考文献

产品说明书

Anti-Human WRAP53 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human WRAP53 Polyclonal Antibody (HA912014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human WRAP53 Polyclonal Antibody (HA912014)

概述

图片

参考文献

产品说明书

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