Anti-Human PTPN22 Polyclonal Antibody (HB930014)

价格:

规格：

50ug
100ug

数量：

联系我们

一键复制产品信息

概述
图片
参考文献
产品说明书

概述

货号

HB930014

品牌

abinScience

描述

Anti-Human PTPN22 Polyclonal Antibody (HB930014) is a rabbit polyclonal antibody detecting PTPN22 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human PTPN22 (Met1-Gly303).

靶标

PTPN8, Lymphoid phosphatase, PTPN22, PEST-domain phosphatase, LyP, Tyrosine-protein phosphatase non-receptor type 22, Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP, PEP

纯化方式

Purified by antigen affinity column.

Accession号

Q9Y2R2

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Tyrosine-protein phosphatase non-receptor type 22 (PTPN22) is a ~91 kDa protein. Acts as a negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules. Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue. Dephosphorylates ZAP70 at its activating 'Tyr-493' residue. Dephosphorylates the immune system activator SKAP2.

1. Wu, J. et al. (2006) The Journal of biological chemistry 281, 11002-10. PMID: 16461343

2. Yu, X. et al. (2007) Proceedings of the National Academy of Sciences of the United States of America 104, 19767-72. PMID: 18056643

3. Yu, X. et al. (2011) The Journal of biological chemistry 286, 30526-30534. PMID: 21719704

4. Wang, Y. et al. (2013) Immunity 39, 111-22. PMID: 23871208

5. Spalinger, MR. et al. (2013) PloS one 8, e72384. PMID: 23991106

6. Spalinger, MR. et al. (2016) The Journal of clinical investigation 126, 1783-800. PMID: 27043286

Note

For research use only.

图片

参考文献

产品说明书

Anti-Human PTPN22 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human PTPN22 Polyclonal Antibody (HB930014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human PTPN22 Polyclonal Antibody (HB930014)

概述

图片

参考文献

产品说明书

相关产品推荐

获取报价