| 靶标 | Protein-glutamine deamidase TGM2, TGase II, Heart G alpha(h), Erythrocyte transglutaminase, Protein-glutamine gamma-glutamyltransferase 2, TG(C), Transglutaminase C, Protein-glutamine serotonyltransferase TGM2, tTG, tTgase, Transglutaminase-2, Protein-glutamine noradrenalinyltransferase TGM2, TGM2, TG2, TGase C, Protein G alpha(h), Protein-glutamine histaminyltransferase TGM2, Tissue transglutaminase, hhG alpha(h), G(h), hTG2, Transglutaminase H, Protein-glutamine dopaminyltransferase TGM2, TGC, Isopeptidase TGM2, TGase-2, TGase H, Transglutaminase II |
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| 背景 | Protein-glutamine gamma-glutamyltransferase 2 (TGM2) is a ~77 kDa protein. Calcium-dependent acyltransferase that catalyzes the formation of covalent bonds between peptide-bound glutamine and various primary amines, such as gamma-amino group of peptide-bound lysine, or mono- and polyamines, thereby producing cross-linked or aminated proteins, respectively. Involved in many biological processes, such as bone development, angiogenesis, wound healing, cellular differentiation, chromatin modification and apoptosis. Acts as a protein-glutamine gamma-glutamyltransferase by mediating the cross-linking of proteins, such as ACO2, HSPB6, FN1, HMGB1, RAP1GDS1, SLC25A4/ANT1, SPP1 and WDR54. Under physiological conditions, the protein cross-linking activity is inhibited by GTP; inhibition is relieved by Ca(2+) in response to various stresses. When secreted, catalyzes cross-linking of proteins of the extracellular matrix, such as FN1 and SPP1 resulting in the formation of scaffolds. 1. De Laurenzi, V. et al. (2001) Molecular and cellular biology 21, 148-55. PMID: 111131892. Nanda, N. et al. (2001) The Journal of biological chemistry 276, 20673-8. PMID: 112741713. Santhanam, L. et al. (2010) Circulation research 107, 117-25. PMID: 204891654. Szondy, Z. et al. (2003) Proceedings of the National Academy of Sciences of the United States of America 100, 7812-7. PMID: 128109615. Falasca, L. et al. (2005) Journal of immunology (Baltimore, Md. : 1950) 174, 7330-40. PMID: 159055806. Liu, B. et al. (2019) Frontiers in pharmacology 10, 1611. PMID: 32116663 |
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