Anti-Mouse FOLR1 Polyclonal Antibody (MB825014)

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概述
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参考文献
产品说明书

概述

货号

MB825014

品牌

abinScience

描述

Anti-Mouse FOLR1 Polyclonal Antibody (MB825014) is a rabbit polyclonal antibody detecting FOLR1 in ELISA, IHC, WB. Suitable for Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Mouse

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Mouse FOLR1 (Asp53-Ser198).

靶标

Folate receptor alpha, FOLR, FOLR1, Adult folate-binding protein, Folate receptor 1, FR-alpha, KB cells FBP, FBP, Ovarian tumor-associated antigen MOv18, Folate receptor, adult

纯化方式

Purified by antigen affinity column.

Accession号

P35846

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Folate receptor alpha (FOLR1) is a ~29 kDa protein. Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. Required for renal folate reabsorption. FOLR1 is the therapeutic target of mirvetuximab soravtansine (Elahere).

1. Brigle, KE. et al. (1991) The Journal of biological chemistry 266, 17243-9. PMID: 1894617

2. Piedrahita, JA. et al. (1999) Nature genetics 23, 228-32. PMID: 10508523

3. Tang, LS. et al. (2003) Birth defects research. Part A, Clinical and molecular teratology 67, 209-18. PMID: 12854656

4. Tang, LS. et al. (2004) Birth defects research. Part A, Clinical and molecular teratology 70, 449-58. PMID: 15259034

5. Zhu, H. et al. (2007) Birth defects research. Part A, Clinical and molecular teratology 79, 257-68. PMID: 17286298

6. Birn, H. et al. (2005) Journal of the American Society of Nephrology : JASN 16, 608-15. PMID: 15703271

Note

For research use only.

图片

参考文献

产品说明书

Anti-Mouse FOLR1 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Mouse FOLR1 Polyclonal Antibody (MB825014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Mouse FOLR1 Polyclonal Antibody (MB825014)

概述

图片

参考文献

产品说明书

相关产品推荐

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