Anti-Mouse TIMD4/TIM-4 Polyclonal Antibody (MP042014)

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概述
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参考文献
产品说明书

概述

货号

MP042014

品牌

abinScience

描述

Anti-Mouse TIMD4/TIM-4 Polyclonal Antibody (MP042014) is a rabbit polyclonal antibody detecting TIMD4 in ELISA, IHC, WB. Suitable for Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Mouse

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Mouse TIMD4/TIM-4 (Glu25-Arg133).

靶标

TIMD4, T-cell immunoglobulin mucin receptor 4, TIM-4, TIMD-4, T-cell membrane protein 4, TIM4, T-cell immunoglobulin and mucin domain-containing protein 4

纯化方式

Purified by antigen affinity column.

Accession号

Q6U7R4

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD4/TIM-4) is a ~37 kDa protein. Phosphatidylserine receptor that plays different role in immune response including phagocytosis of apoptotic cells and T-cell regulation. Controls T-cell activation in a bimodal fashion, decreasing the activation of naive T-cells by inducing cell cycle arrest, while increasing proliferation of activated T-cells by activating AKT1 and ERK1/2 phosphorylations and subsequent signaling pathways. Also plays a role in efferocytosis which is the process by which apoptotic cells are removed by phagocytic cells. Mechanistically, promotes the engulfment of apoptotic cells or exogenous particles by securing them to phagocytes through direct binding to phosphatidylserine present on apoptotic cells, while other engulfment receptors such as MERTK efficiently recognize apoptotic cells and mediate their ingestion. Additionally, promotes autophagy process by suppressing NLRP3 inflammasome activity via activation of STK11/PRKAA1 pathway in a phosphatidylserine-dependent mechanism.

1. Miyanishi, M. et al. (2007) Nature 450, 435-9. PMID: 17960135

2. Rodriguez-Manzanet, R. et al. (2008) Journal of immunology (Baltimore, Md. : 1950) 180, 4706-13. PMID: 18354194

3. Mizui, M. et al. (2008) International immunology 20, 695-708. PMID: 18367551

4. Liu, W. et al. (2019) Journal of immunology (Baltimore, Md. : 1950) 203, 990-1000. PMID: 31263038

Note

For research use only.

图片

参考文献

产品说明书

Anti-Mouse TIMD4/TIM-4 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Mouse TIMD4/TIM-4 Polyclonal Antibody (MP042014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Mouse TIMD4/TIM-4 Polyclonal Antibody (MP042014)

概述

图片

参考文献

产品说明书

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