| 背景 | Angiotensin-converting enzyme 2 (ACE2) is a ~92 kDa protein. Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis. Converts angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II. Also removes the C-terminal residue from three other vasoactive peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin. Also cleaves other biological peptides, such as apelins, casomorphins and dynorphin A. By cleavage of angiotensin II, may be an important regulator of heart function. 2. Donoghue, M. et al. (2003) Journal of molecular and cellular cardiology 35, 1043-53. PMID: 129676274. Kowalczuk, S. et al. (2008) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 22, 2880-7. PMID: 184247685. Camargo, SM. et al. (2009) Gastroenterology 136, 872-82. PMID: 191855826. Fairweather, SJ. et al. (2012) The Biochemical journal 446, 135-48. PMID: 22677001 |
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