Anti-Mouse CLEC6A Polyclonal Antibody (MA366014)

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概述
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参考文献
产品说明书

概述

货号

MA366014

品牌

abinScience

描述

Anti-Mouse CLEC6A Polyclonal Antibody (MA366014) is a rabbit polyclonal antibody detecting CLEC6A in ELISA, IHC, WB. Suitable for Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Mouse

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Mouse CLEC6A (Ile44-Leu209).

靶标

DC-associated C-type lectin 2, DECTIN2, Dendritic cell-associated C-type lectin 2, CLECSF10, CLEC6A, C-type lectin domain family 6 member A, C-type lectin superfamily member 10, Dectin-2

纯化方式

Purified by antigen affinity column.

Accession号

Q9JKF4

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

C-type lectin domain family 6 member A (CLEC6A) is a ~24 kDa protein. Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: specifically recognizes and binds alpha-mannans on C.albicans hypheas. Binding of C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. Also recognizes, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses.

1. Sato, K. et al. (2006) The Journal of biological chemistry 281, 38854-66. PMID: 17050534

2. Robinson, MJ. et al. (2009) The Journal of experimental medicine 206, 2037-51. PMID: 19703985

3. Saijo, S. et al. (2010) Immunity 32, 681-91. PMID: 20493731

4. Campuzano, A. et al. (2020) Journal of immunology (Baltimore, Md. : 1950) 204, 3296-3306. PMID: 32358020

5. Barrett, NA. et al. (2009) Journal of immunology (Baltimore, Md. : 1950) 182, 1119-28. PMID: 19124755

6. Ritter, M. et al. (2010) Proceedings of the National Academy of Sciences of the United States of America 107, 20459-64. PMID: 21059925

Note

For research use only.

图片

参考文献

产品说明书

Anti-Mouse CLEC6A Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Mouse CLEC6A Polyclonal Antibody (MA366014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Mouse CLEC6A Polyclonal Antibody (MA366014)

概述

图片

参考文献

产品说明书

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