Anti-Human IGFBP1 Polyclonal Antibody (HY471014)

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规格：

50ug
100ug

数量：

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概述
图片
参考文献
产品说明书

概述

货号

HY471014

品牌

abinScience

描述

Anti-Human IGFBP1 Polyclonal Antibody (HY471014) is a rabbit polyclonal antibody detecting IGFBP1 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant Human IGFBP1 (Ala26-Asn259).

靶标

IGFBP-1, IGFBP1, Insulin-like growth factor-binding protein 1, Placental protein 12, IBP1, IGF-binding protein 1, IBP-1, PP12

纯化方式

Purified by antigen affinity column.

Accession号

P08833

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Insulin-like growth factor-binding protein 1 (IGFBP1) is a ~27 kDa protein. Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including cell migration, proliferation, differentiation or apoptosis in a cell-type specific manner. Also plays a positive role in cell migration by interacting with integrin ITGA5:ITGB1 through its RGD motif. Mechanistically, binding to integrins leads to activation of focal adhesion kinase/PTK2 and stimulation of the mitogen-activated protein kinase (MAPK) pathway. Regulates cardiomyocyte apoptosis by suppressing HIF-1alpha/HIF1A ubiquitination and subsequent degradation.

1. Gleeson, LM. et al. (2001) The Journal of clinical endocrinology and metabolism 86, 2484-93. PMID: 11397844

2. Sala, A. et al. (2005) The Journal of biological chemistry 280, 29812-9. PMID: 15972819

3. Jones, JI. et al. (1993) Proceedings of the National Academy of Sciences of the United States of America 90, 10553-7. PMID: 7504269

Note

For research use only.

图片

Western blot

Western blot analysis was performed using anti-IGFBP1 polyclonal antibody at 1ug/mL on various samples.
Lane 1: HepG2 cell lysate

参考文献

产品说明书

Anti-Human IGFBP1 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human IGFBP1 Polyclonal Antibody (HY471014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human IGFBP1 Polyclonal Antibody (HY471014)

概述

图片

参考文献

产品说明书

相关产品推荐

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