Anti-Human OTUD1 Polyclonal Antibody (HA252014)

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50ug
100ug

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概述
图片
参考文献
产品说明书

概述

货号

HA252014

品牌

abinScience

描述

Anti-Human OTUD1 Polyclonal Antibody (HA252014) is a rabbit polyclonal antibody detecting OTUD1 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human OTUD1 (Met1-Ser481).

靶标

DUBA7, DUBA-7, OTUD1, OTU domain-containing protein 1, OTDC1

纯化方式

Purified by antigen affinity column.

Accession号

Q5VV17

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

OTU domain-containing protein 1 (OTUD1) is a ~51 kDa protein. Deubiquitinating enzyme that specifically hydrolyzes 'Lys-63'-linked polyubiquitin to monoubiquitin. Required for the stability and translation of a subset mRNAs with a high abundance of rare codons by mediating deubiquitination of 40S ribosomal protein RPS10/eS10, thereby antagonizing ZNF598-mediated 40S ubiquitination. The abundance of rare codons in mRNAs can limit the translation rate and can lead to ribosome collisions that trigger activation of ribosome quality control (RQC) pathway by ZNF598. OTUD1-mediated deubiquitination prevents activation of the RQC and subsequent dissociation of ribosomes and stimulates formation of polysomes and translation.

1. Mevissen, TE. et al. (2013) Cell 154, 169-84. PMID: 23827681

2. Snaurova, R. et al. (2022) Molecular and cellular biology 42, e0026522. PMID: 36445135

Note

For research use only.

图片

参考文献

产品说明书

Anti-Human OTUD1 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human OTUD1 Polyclonal Antibody (HA252014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human OTUD1 Polyclonal Antibody (HA252014)

概述

图片

参考文献

产品说明书

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