Anti-IGFBP3 Polyclonal Antibody (HB776024)

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概述
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参考文献
产品说明书

概述

货号

HB776024

品牌

abinScience

描述

Anti-IGFBP3 Polyclonal Antibody (HB776024) is a rabbit polyclonal antibody detecting IGFBP3 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human IGFBP3 (Gly28-Lys291).

靶标

IBP-3, Insulin-like growth factor-binding protein 3, IGF-binding protein 3, IBP3, IGFBP-3, IGFBP3

纯化方式

Purified by antigen affinity column.

Accession号

P17936

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Insulin-like growth factor-binding protein 3 (IGFBP3) is a ~31 kDa protein. Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. Inhibits the positive effect of humanin on insulin sensitivity. Promotes testicular germ cell apoptosis. Acts via LRP-1/alpha2M receptor, also known as TGF-beta type V receptor, to mediate cell growth inhibition independent of IGF1.

1. Liu, B. et al. (2000) The Journal of biological chemistry 275, 33607-13. PMID: 10874028

2. Cobb, LJ. et al. (2009) Molecular endocrinology (Baltimore, Md.) 23, 1624-33. PMID: 19556345

3. Ingermann, AR. et al. (2010) The Journal of biological chemistry 285, 30233-46. PMID: 20353938

4. Muzumdar, RH. et al. (2009) PloS one 4, e6334. PMID: 19623253

5. Lue, Y. et al. (2010) Endocrinology 151, 350-7. PMID: 19952275

6. Leal, SM. et al. (1997) The Journal of biological chemistry 272, 20572-6. PMID: 9252371

7. Huang, SS. et al. (2004) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 18, 1719-21. PMID: 15371331

Note

For research use only.

图片

参考文献

产品说明书

Anti-IGFBP3 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-IGFBP3 Polyclonal Antibody (HB776024)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-IGFBP3 Polyclonal Antibody (HB776024)

概述

图片

参考文献

产品说明书

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