| 背景 | Adenosine receptor A3 (ADORA3) is a ~36 kDa protein. G protein-coupled receptor (GPCR) for adenosine that plays significant roles in various physiological processes including immune regulation, cardioprotection and neuroprotection. Also acts as a receptor for adenosines containing N(6)-methylated adenine (m6A) post-transcriptional modification, which are derived from the degradation of RNAs (mRNAs, rRNAs and tRNAs): activated by N(6)-methyladenosine (m6A), N(6),N(6)-dimethyladenosine (m6,6A) and N(6)-isopentenyladenosine (i6A). Preferentially couples to the inhibitory G protein (Gi), leading to the suppression of adenylate cyclase activity and a reduction in intracellular cyclic AMP levels. Upon adenosine binding, mediates cardioprotection in cardiomyocytes through anti-apoptotic effects primarily via the ERK1/2 pathway as well as the PI3K pathway. In the central nervous system, participates in the modulation of synaptic plasticity, including long-term potentiation (LTP) and long-term depression (LTD) in the hippocampus. 1. Cai, H. et al. (2024) Nature communications 15, 3252. PMID: 386273842. Zhang, L. et al. (2025) Nature communications 16, 7674. PMID: 408259473. Dougherty, C. et al. (1998) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 12, 1785-92. PMID: 98378694. Ogawa, A. et al. (2021) Molecular cell 81, 659-674.e7. PMID: 334720585. Oshima, HS. et al. (2024) Nature communications 15, 9294. PMID: 395111456. Bouma, MG. et al. (1997) Journal of immunology (Baltimore, Md. : 1950) 158, 5400-8. PMID: 9164961 |
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