Anti-CYP26A1 Polyclonal Antibody (HT346024)

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100ug

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概述
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参考文献
产品说明书

概述

货号

HT346024

品牌

abinScience

描述

Anti-CYP26A1 Polyclonal Antibody (HT346024) is a rabbit polyclonal antibody detecting CYP26A1 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

种属反应性

Human, Mouse

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant Human CYP26A1 (Lys361-Ile503).

靶标

P450RAI1, Cytochrome P450 26A1, Cytochrome P450RAI, hP450RAI, CYP26A1, Cytochrome P450 retinoic acid-inactivating 1, Retinoic acid-metabolizing cytochrome, CYP26, Retinoic acid 4-hydroxylase

纯化方式

Purified by antigen affinity column.

Accession号

O43174

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Cytochrome P450 26A1 (CYP26A1) is a ~56 kDa protein. A cytochrome P450 monooxygenase involved in the metabolism of retinoates (RAs), the active metabolites of vitamin A, and critical signaling molecules in animals. RAs exist as at least four different isomers: all-trans-RA (atRA), 9-cis-RA, 13-cis-RA, and 9,13-dicis-RA, where atRA is considered to be the biologically active isomer, although 9-cis-RA and 13-cis-RA also have activity (Probable). Catalyzes the hydroxylation of atRA primarily at C-4 and C-18, thereby contributing to the regulation of atRA homeostasis and signaling. Hydroxylation of atRA limits its biological activity and initiates a degradative process leading to its eventual elimination (Probable). Involved in the convertion of atRA to all-trans-4-oxo-RA.

1. Topletz, AR. et al. (2012) Biochemical pharmacology 83, 149-63. PMID: 22020119

2. White, JA. et al. (1997) The Journal of biological chemistry 272, 18538-41. PMID: 9228017

3. Sonneveld, E. et al. (1998) Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 9, 629-37. PMID: 9716180

4. Foti, RS. et al. (2016) The Journal of pharmacology and experimental therapeutics 357, 281-92. PMID: 26937021

Note

For research use only.

图片

参考文献

产品说明书

Anti-CYP26A1 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-CYP26A1 Polyclonal Antibody (HT346024)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-CYP26A1 Polyclonal Antibody (HT346024)

概述

图片

参考文献

产品说明书

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