Anti-Human AKAP8 Polyclonal Antibody (HT110014)

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100ug

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概述
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参考文献
产品说明书

概述

货号

HT110014

品牌

abinScience

描述

Anti-Human AKAP8 Polyclonal Antibody (HT110014) is a rabbit polyclonal antibody detecting AKAP8 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human AKAP8 (Met1-Glu572).

靶标

AKAP8, A-kinase anchor protein 8, AKAP95, AKAP-8, A-kinase anchor protein 95 kDa, AKAP 95

纯化方式

Purified by antigen affinity column.

Accession号

O43823

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

A-kinase anchor protein 8 (AKAP8) is a ~76 kDa protein. Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II). Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is required for maintenance of chromosomes in a condensed form throughout mitosis. Recruits condensin complex subunit NCAPD2 to chromosomes required for chromatin condensation; the function appears to be independent from PKA-anchoring. May help to deliver cyclin D/E to CDK4 to facilitate cell cycle progression. Required for cell cycle G2/M transition and histone deacetylation during mitosis.

1. Eide, T. et al. (1998) Experimental cell research 238, 305-16. PMID: 9473338

2. Collas, P. et al. (1999) The Journal of cell biology 147, 1167-80. PMID: 10601332

3. Steen, RL. et al. (2000) The Journal of cell biology 149, 531-6. PMID: 10791967

4. Eide, T. et al. (2002) EMBO reports 3, 426-32. PMID: 11964380

5. Arsenijevic, T. et al. (2004) The Biochemical journal 378, 673-9. PMID: 14641107

6. Li, Y. et al. (2006) Genes & development 20, 2566-79. PMID: 16980585

7. Gao, X. et al. (2012) Molecular biology of the cell 23, 503-15. PMID: 22130794

8. Eide, T. et al. (2003) The Journal of biological chemistry 278, 26750-6. PMID: 12740381

9. Jiang, H. et al. (2013) Nature structural & molecular biology 20, 1156-63. PMID: 23995757

10. Kamada, S. et al. (2005) Molecular and cellular biology 25, 9469-77. PMID: 16227597

Note

For research use only.

图片

参考文献

产品说明书

Anti-Human AKAP8 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human AKAP8 Polyclonal Antibody (HT110014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human AKAP8 Polyclonal Antibody (HT110014)

概述

图片

参考文献

产品说明书

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