| 靶标 | Type I iodothyronine deiodinase, 1.21.99.4, 5DI, DIOI, Type 1 DI, Type-I 5'-deiodinase, DIO1, ITDI1, TXDI1 |
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| 背景 | Type I iodothyronine deiodinase (DIO1) is a ~28 kDa protein. Plays a crucial role in the metabolism of thyroid hormones (TH) and has specific roles in TH activation and inactivation by deiodination. Catalyzes the deiodination of L-thyroxine (T4) to 3,5,3'-triiodothyronine (T3), 3,3',5'-triiodothyronine (rT3) to 3,3'-diiodothyronine (3,3'-T2) and 3',5'-diiodothyronine (3',5'-T2) to 3'-monoiodothyronine (3'-T1) via outer-ring deiodination (ORD). Catalyzes the deiodination of T4 to 3,3',5'-triiodothyronine (rT3) via inner-ring deiodination (IRD). Catalyzes the deiodination of T3 to 3,3'-T2, 3,5-diiodothyronine (3,5-T2) to 3- monoiodothyronine (3-T1) and 3,3'-T2 to 3-T1 via IRD. Catalyzes the phenolic ring deiodinations of 3,3',5'-triiodothyronamine and 3',5'-diiodothyronamine. 1. Curcio-Morelli, C. et al. (2003) Endocrinology 144, 937-46. PMID: 125867712. França, MM. et al. (2021) Thyroid : official journal of the American Thyroid Association 31, 202-207. PMID: 327182243. Piehl, S. et al. (2008) Rapid communications in mass spectrometry : RCM 22, 3286-96. PMID: 18821722 |
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