Anti-TERF2 Polyclonal Antibody (HS853014)

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概述
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产品说明书

概述

货号

HS853014

品牌

abinScience

描述

Anti-TERF2 Polyclonal Antibody (HS853014) is a rabbit polyclonal antibody detecting TERF2 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human TERF2 (Arg144-Gln438).

靶标

Telomeric repeat-binding factor 2, Telomeric DNA-binding protein, TERF2, TRBF2, TTAGGG repeat-binding factor 2, TRF2

纯化方式

Purified by antigen affinity column.

Accession号

Q15554

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Telomeric repeat-binding factor 2 (TERF2) is a ~59 kDa protein. Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair.

1. Court, R. et al. (2005) EMBO reports 6, 39-45. PMID: 15608617

2. de Lange, T. (2005) Genes & development 19, 2100-10. PMID: 16166375

3. Ye, J. et al. (2010) Cell 142, 230-42. PMID: 20655466

4. Rai, R. et al. (2017) Molecular cell 65, 801-817.e4. PMID: 28216226

5. Li, P. et al. (2019) International journal of biological sciences 15, 2350-2362. PMID: 31595153

6. Broccoli, D. et al. (1997) Nature genetics 17, 231-5. PMID: 9326950

7. Bilaud, T. et al. (1997) Nature genetics 17, 236-9. PMID: 9326951

8. van Steensel, B. et al. (1998) Cell 92, 401-13. PMID: 9476899

Note

For research use only.

图片

参考文献

产品说明书

Anti-TERF2 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-TERF2 Polyclonal Antibody (HS853014)

概述

图片

参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Anti-TERF2 Polyclonal Antibody (HS853014)

概述

图片

参考文献

产品说明书

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