| 靶标 | CD151 antigen, GP27, Membrane glycoprotein SFA-1, Platelet-endothelial tetraspan antigen 3, PETA-3, Tetraspanin-24, Tspan-24, CD151, CD151, TSPAN24 |
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| 背景 | CD151 antigen is a ~28 kDa protein. Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Plays a role in various cellular and molecular mechanism through its association with both integrin and non-integrin proteins. These interactions facilitate critical cellular functions, including cell-to-cell communication, wound healing, platelet aggregation, trafficking, cell motility, and angiogenesis. Via interaction with JAM-A/F11R and integrin ITGA3:ITGB1, promotes the recruitment of signaling molecules such as RAC1, CDC42 and RhoGTPases to facilitate the polarization of epithelial cells and the reorganization of the actin cytoskeleton, which are critical steps in cell migration process. Regulates the glycosylation pattern of ITGA3:ITGB1 thereby modulating its activity. 1. Zheng, ZZ. et al. (2007) The international journal of biochemistry & cell biology 39, 340-8. PMID: 170458342. Rocha-Perugini, V. et al. (2014) European journal of immunology 44, 1967-75. PMID: 247233893. Te Molder, L. et al. (2019) Journal of cell science 132. PMID: 314885074. Hong, IK. et al. (2012) The Journal of biological chemistry 287, 32027-39. PMID: 228436935. Thölmann, S. et al. (2022) Cellular and molecular life sciences : CMLS 79, 88. PMID: 350678326. Baldwin, G. et al. (2008) The Journal of biological chemistry 283, 35445-54. PMID: 188522637. Karamatic Crew, V. et al. (2004) Blood 104, 2217-23. PMID: 15265795 |
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