| 靶标 | Transcription initiation factor TFIID subunit 4, RNA polymerase II TBP-associated factor subunit C, TBP-associated factor 4, Transcription initiation factor TFIID 130 kDa subunit, TAF(II)130, TAFII-130, TAFII130, Transcription initiation factor TFIID 135 kDa subunit, TAF(II)135, TAFII-135, TAFII135, TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135 |
|---|
| 背景 | Transcription initiation factor TFIID subunit 4 (TAF4) is a ~110 kDa protein. The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. TAF4 may maintain an association between the TFIID and TFIIA complexes, while bound to the promoter, together with TBP, during PIC assembly. Potentiates transcriptional activation by the AF-2S of the retinoic acid, vitamin D3 and thyroid hormone. 1. Chen, X. et al. (2021) Science (New York, N.Y.) 372. PMID: 337954732. Gangloff, YG. et al. (2000) Molecular and cellular biology 20, 340-51. PMID: 105940363. Tanese, N. et al. (1996) Proceedings of the National Academy of Sciences of the United States of America 93, 13611-6. PMID: 89429824. Mengus, G. et al. (1997) Genes & development 11, 1381-95. PMID: 9192867 |
|---|
