Anti-Human TM4SF5 Polyclonal Antibody (HT023014)

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概述
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参考文献
产品说明书

概述

货号

HT023014

品牌

abinScience

描述

Anti-Human TM4SF5 Polyclonal Antibody (HT023014) is a rabbit polyclonal antibody detecting TM4SF5 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human TM4SF5 (Leu112-Thr157).

靶标

Transmembrane 4 L6 family member 5, Tetraspan transmembrane protein L6H, TM4SF5

纯化方式

Purified by antigen affinity column.

Accession号

O14894

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Transmembrane 4 L6 family member 5 (TM4SF5) is a ~20 kDa protein. Acts as a lysosomal membrane arginine sensor. Forms a complex with MTOR and SLC38A9 on lysosomal membranes in an arginine-regulated manner, leading to arginine efflux which enables the activation of mTORC1 which subsequently leads to RPS6KB1 and EIF4EBP1 phosphorylations. Facilitates cell cycle G1/S phase progression and the translocation of the CDK4-CCND1 complex into the nucleus. CDKN1B and RHOA/ROCK signaling activity are involved in TM4SF5-mediated acceleration of G1/S phase progression.

1. Jung, JW. et al. (2019) Cell metabolism 29, 1306-1319.e7. PMID: 30956113

2. Kim, H. et al. (2010) Biochimica et biophysica acta 1803, 975-82. PMID: 20399237

Note

For research use only.

图片

参考文献

产品说明书

Anti-Human TM4SF5 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human TM4SF5 Polyclonal Antibody (HT023014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human TM4SF5 Polyclonal Antibody (HT023014)

概述

图片

参考文献

产品说明书

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