ATP-binding cassette sub-family C member 5 (ABCC5) is a ~160 kDa protein. ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of endogenous metabolites such as cAMP and cGMP, folic acid and N-lactoyl-amino acids (in vitro). Also acts as a general glutamate conjugate and analog transporter that can limit the brain levels of endogenous metabolites, drugs, and toxins. Confers resistance to the antiviral agent PMEA. Able to transport several anticancer drugs including methotrexate, and nucleotide analogs in vitro, however it does with low affinity, thus the exact role of ABCC5 in mediating resistance still needs to be elucidated. 1. Jedlitschky, G. et al. (2000) The Journal of biological chemistry 275, 30069-74. PMID: 108932472. Wielinga, PR. et al. (2003) The Journal of biological chemistry 278, 17664-71. PMID: 126375263. Reid, G. et al. (2003) Molecular pharmacology 63, 1094-103. PMID: 126955384. Wielinga, P. et al. (2005) Cancer research 65, 4425-30. PMID: 158998355. de Wolf, CJ. et al. (2007) The FEBS journal 274, 439-50. PMID: 172291496. Jansen, RS. et al. (2015) Proceedings of the National Academy of Sciences of the United States of America 112, 6601-6. PMID: 259643437. Jansen, RS. et al. (2015) The Journal of biological chemistry 290, 30429-40. PMID: 265150618. Wijnholds, J. et al. (2000) Proceedings of the National Academy of Sciences of the United States of America 97, 7476-81. PMID: 108400509. Wielinga, PR. et al. (2002) Molecular pharmacology 62, 1321-31. PMID: 12435799 | 
