

| 货号 | HF922014 | ||||||||
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| 品牌 | abinScience | ||||||||
| 描述 |
Anti-Human CIB2 Polyclonal Antibody (HF922014) is a rabbit polyclonal antibody detecting CIB2 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 种属反应性 | Human, Mouse, Rat | ||||||||
| 应用 | ELISA, IHC, WB | ||||||||
| 宿主 | Rabbit | ||||||||
| 克隆类型 | Polyclonal | ||||||||
| 同种型 | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CIB2 (Met1-Ile187). | ||||||||
| 靶标 | Calcium and integrin-binding family member 2, Kinase-interacting protein 2, KIP 2, CIB2, KIP2 | ||||||||
| 纯化方式 | Purified by antigen affinity column. | ||||||||
| Accession号 | O75838 | ||||||||
| 状态 | Liquid | ||||||||
| 保存溶液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| 产品使用信息 |
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| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Calcium and integrin-binding family member 2 (CIB2) is a ~21 kDa protein. Calcium- and integrin-binding protein that plays a role in intracellular calcium homeostasis. Acts as an auxiliary subunit of the sensory mechanoelectrical transduction (MET) channel in hair cells. Essential for mechanoelectrical transduction (MET) currents in auditory hair cells and thereby required for hearing. Regulates the function of hair cell mechanotransduction by controlling the distribution of transmembrane channel-like proteins TMC1 and TMC2, and by regulating the function of the MET channels in hair cells. Required for the maintenance of auditory hair cell stereocilia bundle morphology and function and for hair-cell survival in the cochlea. 1. Riazuddin, S. et al. (2012) Nature genetics 44, 1265-71. PMID: 23023331 2. Seco, CZ. et al. (2016) European journal of human genetics : EJHG 24, 542-9. PMID: 26173970 3. Patel, K. et al. (2015) PloS one 10, e0133082. PMID: 26426422 | ||||||||
| Note | For research use only. |

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