| 靶标 | Gamma-aminobutyric acid type B receptor subunit 2, GABA-B receptor 2, GABA-B-R2, GABA-BR2, GABABR2, Gb2, G-protein coupled receptor 51, HG20, GABBR2, GPR51, GPRC3B |
|---|
| 背景 | Gamma-aminobutyric acid type B receptor subunit 2 (GABBR2) is a ~105 kDa protein. Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. 1. Villemure, JF. et al. (2005) The Biochemical journal 388, 47-55. PMID: 156175122. Nomura, R. et al. (2008) The Journal of biological chemistry 283, 4665-73. PMID: 181656883. Geng, Y. et al. (2012) Nature neuroscience 15, 970-8. PMID: 226604776. Kuner, R. et al. (1999) Science (New York, N.Y.) 283, 74-7. PMID: 98727447. Ng, GY. et al. (1999) The Journal of biological chemistry 274, 7607-10. PMID: 100756448. Sullivan, R. et al. (2000) The Journal of pharmacology and experimental therapeutics 293, 460-7. PMID: 10773016 |
|---|
