Anti-Human RAD17 Polyclonal Antibody (HF857014)

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100ug

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概述
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参考文献
产品说明书

概述

货号

HF857014

品牌

abinScience

描述

Anti-Human RAD17 Polyclonal Antibody (HF857014) is a rabbit polyclonal antibody detecting RAD17 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human RAD17 (Lys96-Pro353).

靶标

Cell cycle checkpoint protein RAD17, hRad17, RF-C/activator 1 homolog, RAD17, R24L

纯化方式

Purified by antigen affinity column.

Accession号

O75943

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Cell cycle checkpoint protein RAD17 is a ~77 kDa protein. Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the 9-1-1 (RAD1-RAD9-HUS1) complex and RHNO1 onto chromatin, and in CHEK1 activation. Involved in homologous recombination by mediating recruitment of the MRN complex to DNA damage sites. May also serve as a sensor of DNA replication progression.

1. Li, L. et al. (1999) Oncogene 18, 1689-99. PMID: 10208430

2. Bao, S. et al. (2001) Nature 411, 969-74. PMID: 11418864

3. Post, S. et al. (2001) Proceedings of the National Academy of Sciences of the United States of America 98, 13102-7. PMID: 11687627

4. Zou, L. et al. (2002) Genes & development 16, 198-208. PMID: 11799063

5. Wang, X. et al. (2003) Genes & development 17, 965-70. PMID: 12672690

6. Ellison, V. et al. (2003) PLoS biology 1, E33. PMID: 14624239

7. Garg, R. et al. (2004) Molecular cancer research : MCR 2, 362-9. PMID: 15235112

8. Cotta-Ramusino, C. et al. (2011) Science (New York, N.Y.) 332, 1313-7. PMID: 21659603

10. Bermudez, VP. et al. (2003) Proceedings of the National Academy of Sciences of the United States of America 100, 1633-8. PMID: 12578958

Note

For research use only.

图片

参考文献

产品说明书

Anti-Human RAD17 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human RAD17 Polyclonal Antibody (HF857014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human RAD17 Polyclonal Antibody (HF857014)

概述

图片

参考文献

产品说明书

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