Anti-Human KCNK2 Polyclonal Antibody (HF823014)

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概述
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参考文献
产品说明书

概述

货号

HF823014

品牌

abinScience

描述

Anti-Human KCNK2 Polyclonal Antibody (HF823014) is a rabbit polyclonal antibody detecting KCNK2 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Human, Mouse, Rat

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant Human KCNK2 (Asp309-Lys426).

靶标

Potassium channel subfamily K member 2, Outward rectifying potassium channel protein TREK-1, TREK-1 K(+) channel subunit, Two pore domain potassium channel TREK-1, Two pore potassium channel TPKC1, KCNK2, TREK, TREK1

纯化方式

Purified by antigen affinity column.

Accession号

O95069

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Potassium channel subfamily K member 2 (KCNK2) is a ~47 kDa protein. K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate. Converts to voltage-independent 'leak' conductance mode upon stimulation by various stimuli including mechanical membrane stretch, acidic pH, heat and lipids. Reversibly converts between a voltage-insensitive K(+) 'leak' channel and a voltage-dependent outward rectifying K(+) channel in a phosphorylation-dependent manner. Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties.

1. Patel, AJ. et al. (1999) Nature neuroscience 2, 422-6. PMID: 10321245

2. Meadows, HJ. et al. (2000) Pflugers Archiv : European journal of physiology 439, 714-22. PMID: 10784345

3. Bockenhauer, D. et al. (2001) Nature neuroscience 4, 486-91. PMID: 11319556

4. Plant, LD. et al. (2012) Science signaling 5, ra84. PMID: 23169818

5. Royal, P. et al. (2019) Neuron 101, 232-245.e6. PMID: 30573346

6. Sorum, B. et al. (2024) Nature communications 15, 3142. PMID: 38605031

Note

For research use only.

图片

参考文献

产品说明书

Anti-Human KCNK2 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human KCNK2 Polyclonal Antibody (HF823014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human KCNK2 Polyclonal Antibody (HF823014)

概述

图片

参考文献

产品说明书

相关产品推荐

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