Leukotriene A-4 hydrolase (LTA4H) is a ~69 kDa protein. Bifunctional zinc metalloenzyme that comprises both epoxide hydrolase (EH) and aminopeptidase activities. Acts as an epoxide hydrolase to catalyze the conversion of LTA4 to the pro-inflammatory mediator leukotriene B4 (LTB4). Can utilize LTA5 less effectively as a substrate than LTA4, and produce LTB5. Also has aminopeptidase activity, with high affinity for N-terminal arginines of various synthetic tripeptides. In addition to its pro-inflammatory EH activity, may also counteract inflammation by its aminopeptidase activity, which inactivates by cleavage another neutrophil attractant, the tripeptide Pro-Gly-Pro (PGP), a bioactive fragment of collagen generated by the action of matrix metalloproteinase-9 (MMP9) and prolylendopeptidase (PREPL). 1. Rudberg, PC. et al. (2002) Proceedings of the National Academy of Sciences of the United States of America 99, 4215-20. PMID: 119171242. Thunnissen, MM. et al. (2002) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 16, 1648-50. PMID: 122070023. Rudberg, PC. et al. (2004) The Journal of biological chemistry 279, 27376-82. PMID: 150788704. Tholander, F. et al. (2008) Chemistry & biology 15, 920-9. PMID: 188040295. Odlander, B. et al. (1991) Archives of biochemistry and biophysics 287, 167-74. PMID: 18979886. Toh, H. et al. (1990) Biochemical and biophysical research communications 171, 216-21. PMID: 19754947. Haeggström, JZ. et al. (1990) Biochemical and biophysical research communications 172, 965-70. PMID: 22449218. Nathaniel, DJ. et al. (1985) Biochemical and biophysical research communications 131, 827-35. PMID: 2996528 | 
