Anti-Human TSPAN8 Polyclonal Antibody (HB737014)

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100ug

数量：

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概述
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产品说明书

概述

货号

HB737014

品牌

abinScience

描述

Anti-Human TSPAN8 Polyclonal Antibody (HB737014) is a rabbit polyclonal antibody detecting TSPAN8 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human TSPAN8 (Lys110-Asn205).

靶标

Tetraspanin-8, Tspan-8, Transmembrane 4 superfamily member 3, Tumor-associated antigen CO-029, TSPAN8, TM4SF3

纯化方式

Purified by antigen affinity column.

Accession号

P19075

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Tetraspanin-8 (TSPAN8) is a ~26 kDa protein. Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, migration and protein trafficking. Promotes ADAM17-mediated TNF processing through recruitment of ADAM17 to tetraspanin-enriched micro-domains (TEMs). Forms a complex with RICTOR and integrin alpha3/ITGA3 to mediate mTORC2 activation and AKT1 phosphorylation leading to cell migration. Reduces apoptosis and autophagy induced by high glucose levels through forming a complex with mTOR and RICTOR.

1. Schmidt, F. et al. (2016) Biological chemistry. PMID: 27180357

2. Müller, M. et al. (2022) Cells 11. PMID: 36078095

3. Pan, SJ. et al. (2015) International journal of molecular sciences 16, 5363-74. PMID: 25761241

4. Zhuang, L. et al. (2022) Cell biology international 46, 1693-1703. PMID: 35904232

5. Min, J. et al. (2023) Cellular and molecular life sciences : CMLS 80, 154. PMID: 37204469

6. Zhu, Y. et al. (2023) Cancers 15. PMID: 37835445

Note

For research use only.

图片

参考文献

产品说明书

Anti-Human TSPAN8 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human TSPAN8 Polyclonal Antibody (HB737014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human TSPAN8 Polyclonal Antibody (HB737014)

概述

图片

参考文献

产品说明书

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