GTP-binding nuclear protein Ran is a ~24 kDa protein. GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. 1. Hsiao, PW. et al. (1999) The Journal of biological chemistry 274, 20229-34. PMID: 104006402. Yamashita, D. et al. (2007) The Journal of biological chemistry 282, 7563-75. PMID: 172090483. Rudack, T. et al. (2015) The Journal of biological chemistry 290, 24079-90. PMID: 262726104. Aksu, M. et al. (2016) Nature communications 7, 11952. PMID: 273064585. Melchior, F. et al. (1993) The Journal of cell biology 123, 1649-59. PMID: 82768876. Palacios, I. et al. (1996) The Journal of cell biology 133, 485-94. PMID: 86362257. Moroianu, J. et al. (1996) Proceedings of the National Academy of Sciences of the United States of America 93, 7059-62. PMID: 86929448. Görlich, D. et al. (1996) The EMBO journal 15, 5584-94. PMID: 88964529. Izaurralde, E. et al. (1997) The EMBO journal 16, 6535-47. PMID: 935183410. Bischoff, FR. et al. (1997) FEBS letters 419, 249-54. PMID: 9428644 | 
