Anti-Human IL4I1 Polyclonal Antibody (HP675014)

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100ug

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概述
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参考文献
产品说明书

概述

货号

HP675014

品牌

abinScience

描述

Anti-Human IL4I1 Polyclonal Antibody (HP675014) is a rabbit polyclonal antibody detecting IL4I1 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant Human IL4I1 (Gln22-Asn505).

靶标

L-amino-acid oxidase, LAAO, LAO, 1.4.3.2, 1.4.3.25, Interleukin-4-induced protein 1, IL4-induced protein 1, hIL4I1, Protein Fig-1, hFIG1, IL4I1, FIG1, UNQ636/PRO1265

纯化方式

Purified by antigen affinity column.

Accession号

Q96RQ9

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

L-amino-acid oxidase (IL4I1) is a ~62 kDa protein. Secreted L-amino-acid oxidase that acts as a key immunoregulator. Has preference for L-aromatic amino acids: converts phenylalanine (Phe), tyrosine (Tyr) and tryptophan (Trp) to phenylpyruvic acid (PP), hydroxyphenylpyruvic acid (HPP), and indole-3-pyruvic acid (I3P), respectively. Also has weak L-arginine oxidase activity. Acts as a negative regulator of anti-tumor immunity by mediating Trp degradation via an indole pyruvate pathway that activates the transcription factor AHR. IL4I1-mediated Trp catabolism generates I3P, giving rise to indole metabolites (indole-3-acetic acid (IAA) and indole-3-aldehyde (I3A)) and kynurenic acid, which act as ligands for AHR, a ligand-activated transcription factor that plays important roles in immunity and cancer.

1. Boulland, ML. et al. (2007) Blood 110, 220-7. PMID: 17356132

2. Sadik, A. et al. (2020) Cell 182, 1252-1270.e34. PMID: 32818467

3. Zhang, X. et al. (2020) Journal of agricultural and food chemistry 68, 10678-10684. PMID: 32866000

4. Molinier-Frenkel, V. et al. (2016) Genes and immunity 17, 148-52. PMID: 26673964

6. Cousin, C. et al. (2015) European journal of immunology 45, 1772-82. PMID: 25778793

Note

For research use only.

图片

参考文献

产品说明书

Anti-Human IL4I1 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human IL4I1 Polyclonal Antibody (HP675014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human IL4I1 Polyclonal Antibody (HP675014)

概述

图片

参考文献

产品说明书

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