Anti-Human YTHDF3 Polyclonal Antibody (HA146014)

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100ug

数量：

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概述
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参考文献
产品说明书

概述

货号

HA146014

品牌

abinScience

描述

Anti-Human YTHDF3 Polyclonal Antibody (HA146014) is a rabbit polyclonal antibody detecting YTHDF3 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Human, Mouse

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human YTHDF3 (Gly416-Glu572).

靶标

YTH domain-containing family protein 3, DF3, YTHDF3

纯化方式

Purified by antigen affinity column.

Accession号

Q7Z739

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

YTH domain-containing family protein 3 (YTHDF3) is a ~63 kDa protein. Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates their stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex or PAN3. The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) share m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation. Acts as a negative regulator of type I interferon response by down-regulating interferon-stimulated genes (ISGs) expression: acts by binding to FOXO3 mRNAs.

1. Shi, H. et al. (2017) Cell research 27, 315-328. PMID: 28106072

2. Li, A. et al. (2017) Cell research 27, 444-447. PMID: 28106076

3. Yang, Y. et al. (2017) Cell research 27, 626-641. PMID: 28281539

4. Zaccara, S. et al. (2020) Cell 181, 1582-1595.e18. PMID: 32492408

5. Dominissini, D. et al. (2012) Nature 485, 201-6. PMID: 22575960

6. Wang, X. et al. (2014) Nature 505, 117-20. PMID: 24284625

7. Ries, RJ. et al. (2019) Nature 571, 424-428. PMID: 31292544

Note

For research use only.

图片

参考文献

产品说明书

Anti-Human YTHDF3 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human YTHDF3 Polyclonal Antibody (HA146014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human YTHDF3 Polyclonal Antibody (HA146014)

概述

图片

参考文献

产品说明书

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