Anti-Human USP37 Polyclonal Antibody (HA158014)

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规格：

50ug
100ug

数量：

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概述
图片
参考文献
产品说明书

概述

货号

HA158014

品牌

abinScience

描述

Anti-Human USP37 Polyclonal Antibody (HA158014) is a rabbit polyclonal antibody detecting USP37 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Human, Mouse

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human USP37 (Met1-Arg106).

靶标

Ubiquitin carboxyl-terminal hydrolase 37, 3.4.19.12, Deubiquitinating enzyme 37, Ubiquitin thioesterase 37, Ubiquitin-specific-processing protease 37, USP37, KIAA1594

纯化方式

Purified by antigen affinity column.

Accession号

Q86T82

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Ubiquitin carboxyl-terminal hydrolase 37 (USP37) is a ~110 kDa protein. Deubiquitinase that plays a role in different processes including cell cycle regulation, DNA replication or DNA damage response. Antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1.

1. Yeh, C. et al. (2015) Current biology : CB 25, 2290-9. PMID: 26299517

2. Hernández-Pérez, S. et al. (2016) Molecular oncology 10, 1196-206. PMID: 27296872

3. Xiao, Z. et al. (2019) American journal of cancer research 9, 2749-2759. PMID: 31911859

4. Stromberg, BR. et al. (2021) The Journal of biological chemistry 297, 101184. PMID: 34509474

5. Huang, X. et al. (2011) Molecular cell 42, 511-23. PMID: 21596315

6. Wu, C. et al. (2021) Nucleic acids research 49, 11224-11240. PMID: 34606619

Note

For research use only.

图片

Western blot

Western blot analysis was performed using anti-USP37 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Mouse spleen lysate

参考文献

产品说明书

Anti-Human USP37 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human USP37 Polyclonal Antibody (HA158014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human USP37 Polyclonal Antibody (HA158014)

概述

图片

参考文献

产品说明书

相关产品推荐

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