Anti-Human FANCM Polyclonal Antibody (HA265014)

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50ug
100ug

数量：

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概述
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参考文献
产品说明书

概述

货号

HA265014

品牌

abinScience

描述

Anti-Human FANCM Polyclonal Antibody (HA265014) is a rabbit polyclonal antibody detecting FANCM in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human FANCM (Ser281-His620).

靶标

Fanconi anemia group M protein, Protein FACM, 3.6.4.13, ATP-dependent RNA helicase FANCM, Fanconi anemia-associated polypeptide of 250 kDa, FAAP250, Protein Hef ortholog, FANCM, KIAA1596

纯化方式

Purified by antigen affinity column.

Accession号

Q8IYD8

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Fanconi anemia group M protein (FANCM) is a ~232 kDa protein. DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX.

1. Meetei, AR. et al. (2005) Nature genetics 37, 958-63. PMID: 16116422

2. Singh, TR. et al. (2009) Blood 114, 174-80. PMID: 19423727

3. Yan, Z. et al. (2010) Molecular cell 37, 865-78. PMID: 20347428

4. Singh, TR. et al. (2010) Molecular cell 37, 879-86. PMID: 20347429

5. Fouquet, B. et al. (2017) eLife 6. PMID: 29231814

6. Ciccia, A. et al. (2007) Molecular cell 25, 331-43. PMID: 17289582

Note

For research use only.

图片

参考文献

产品说明书

Anti-Human FANCM Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human FANCM Polyclonal Antibody (HA265014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human FANCM Polyclonal Antibody (HA265014)

概述

图片

参考文献

产品说明书

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