Anti-Human USP30 Polyclonal Antibody (HA920014)

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100ug

数量：

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概述
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参考文献
产品说明书

概述

货号

HA920014

品牌

abinScience

描述

Anti-Human USP30 Polyclonal Antibody (HA920014) is a rabbit polyclonal antibody detecting USP30 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Human, Mouse, Rat

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human USP30 (Gly74-Lys355).

靶标

Ubiquitin carboxyl-terminal hydrolase 30, 3.4.19.12, Deubiquitinating enzyme 30, Ubiquitin thioesterase 30, Ubiquitin-specific-processing protease 30, Ub-specific protease 30, USP30

纯化方式

Purified by antigen affinity column.

Accession号

Q70CQ3

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Ubiquitin carboxyl-terminal hydrolase 30 (USP30) is a ~58 kDa protein. Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy. Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate in mitophagic signaling. Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65'. Acts as a negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2.

1. Nakamura, N. et al. (2008) Molecular biology of the cell 19, 1903-11. PMID: 18287522

2. Bingol, B. et al. (2014) Nature 510, 370-5. PMID: 24896179

3. Wauer, T. et al. (2015) The EMBO journal 34, 307-25. PMID: 25527291

4. Cunningham, CN. et al. (2015) Nature cell biology 17, 160-9. PMID: 25621951

Note

For research use only.

图片

参考文献

产品说明书

Anti-Human USP30 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human USP30 Polyclonal Antibody (HA920014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human USP30 Polyclonal Antibody (HA920014)

概述

图片

参考文献

产品说明书

相关产品推荐

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