Anti-Human SUGCT Polyclonal Antibody (HA129014)

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规格：

50ug
100ug

数量：

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概述
图片
参考文献
产品说明书

概述

货号

HA129014

品牌

abinScience

描述

Anti-Human SUGCT Polyclonal Antibody (HA129014) is a rabbit polyclonal antibody detecting SUGCT in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human SUGCT (Gln32-His438).

靶标

Succinate--hydroxymethylglutarate CoA-transferase, 2.8.3.13, Dermal papilla-derived protein 13, SuccinylCoA:glutarate-CoA transferase, SUGCT, C7orf10, DERP13

纯化方式

Purified by antigen affinity column.

Accession号

Q9HAC7

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Succinyl-CoA:glutarate CoA-transferase (SUGCT) is a ~47 kDa protein. Coenzyme A (CoA) transferase that reversibly catalyzes the transfer of a CoA moiety from a dicarboxyl-CoA to a dicarboxylate in a metabolite recycling process. Displays preference for succinyl-CoA and glutarate-CoA as dicarboxyl-CoA donors and glutarate, succinate, adipate/hexanedioate, itaconate and 3-hydroxy-3-methylglutarate as dicarboxylate acceptors. Acts on intermediates or end products of lysine and tryptophan degradation pathway, in particular catalyzes succinyl-CoA-dependent reesterification of free glutarate into glutaryl-CoA to prevent renal excretion of glutarate. Upon inflammation, may convert macrophage-derived itaconate to itaconyl-CoA in erythroid precursors where it negatively regulates the TCA cycle and heme synthesis to limit erythroid differentiation in the context of stress erythropoiesis.

1. Marlaire, S. et al. (2014) Journal of inherited metabolic disease 37, 13-9. PMID: 23893049

2. Marcero, JR. et al. (2021) Blood advances 5, 4831-4841. PMID: 34492704

3. Wu, R. et al. (2024) ACS chemical biology 19, 1544-1553. PMID: 38915184

4. Sherman, EA. et al. (2008) American journal of human genetics 83, 604-9. PMID: 18926513

Note

For research use only.

图片

Western blot

Western blot analysis was performed using anti-SYGCT polyclonal antibody at 1ug/mL on various samples.
Lane 1: Mouse kidney lysate

参考文献

产品说明书

Anti-Human SUGCT Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human SUGCT Polyclonal Antibody (HA129014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human SUGCT Polyclonal Antibody (HA129014)

概述

图片

参考文献

产品说明书

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