| 背景 | Interferon-inducible protein AIM2 is a ~40 kDa protein. Sensor component of the AIM2 inflammasome, which mediates inflammasome activation in response to the presence of double-stranded DNA (dsDNA) in the cytosol, leading to subsequent pyroptosis. Inflammasomes are supramolecular complexes that assemble in the cytosol in response to pathogens and other damage-associated signals and play critical roles in innate immunity and inflammation. Acts as a recognition receptor (PRR): specifically recognizes and binds dsDNA in the cytosol, and mediates the formation of the inflammasome polymeric complex composed of AIM2, CASP1 and PYCARD/ASC. Recruitment of pro-caspase-1 (proCASP1) to the AIM2 inflammasome promotes caspase-1 (CASP1) activation, which subsequently cleaves and activates inflammatory cytokines IL1B and IL18 and gasdermin-D (GSDMD), promoting cytokine secretion. In some cells, CASP1 activation mediates cleavage and activation of GSDMD, triggering pyroptosis without promoting cytokine secretion. 1. Roberts, TL. et al. (2009) Science (New York, N.Y.) 323, 1057-60. PMID: 191315923. Fernandes-Alnemri, T. et al. (2009) Nature 458, 509-13. PMID: 191586764. Bürckstümmer, T. et al. (2009) Nature immunology 10, 266-72. PMID: 191586795. Rathinam, VA. et al. (2010) Nature immunology 11, 395-402. PMID: 203516926. Fernandes-Alnemri, T. et al. (2010) Nature immunology 11, 385-93. PMID: 203516937. Sauer, JD. et al. (2010) Cell host & microbe 7, 412-9. PMID: 204171698. Jones, JW. et al. (2010) Proceedings of the National Academy of Sciences of the United States of America 107, 9771-6. PMID: 204579089. Belhocine, K. et al. (2012) Cellular microbiology 14, 71-80. PMID: 21902795 |
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