

| 货号 | MY349014 | ||||||||
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| 品牌 | abinScience | ||||||||
| 描述 |
Anti-Mouse LCAT Polyclonal Antibody (MY349014) is a rabbit polyclonal antibody detecting Lcat in ELISA, IHC, WB. Suitable for Mouse.
Highlights
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| 种属反应性 | Mouse, Rat | ||||||||
| 应用 | ELISA, IHC, WB | ||||||||
| 宿主 | Rabbit | ||||||||
| 克隆类型 | Polyclonal | ||||||||
| 同种型 | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Mouse LCAT (Phe25-Glu438). | ||||||||
| 靶标 | Phosphatidylcholine-sterol acyltransferase, 2.3.1.43, 1-alkyl-2-acetylglycerophosphocholine esterase, 3.1.1.47, Lecithin-cholesterol acyltransferase, Phospholipid-cholesterol acyltransferase, Platelet-activating factor acetylhydrolase, PAF acetylhydrolase, Lcat | ||||||||
| 纯化方式 | Purified by antigen affinity column. | ||||||||
| Accession号 | P16301 | ||||||||
| 状态 | Liquid | ||||||||
| 保存溶液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| 产品使用信息 |
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| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Phosphatidylcholine-sterol acyltransferase (LCAT) is a ~49 kDa protein. Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. 1. Hirsch-Reinshagen, V. et al. (2009) Journal of lipid research 50, 885-93. PMID: 19065001 2. Subbaiah, PV. et al. (1996) Journal of lipid research 37, 113-22. PMID: 8820107 3. Forte, TM. et al. (1999) Journal of lipid research 40, 1276-83. PMID: 10393212 | ||||||||
| Note | For research use only. |

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