

| 货号 | MW583014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 品牌 | abinScience | ||||||||
| 描述 |
Anti-Mouse GATA4 Polyclonal Antibody (MW583014) is a rabbit polyclonal antibody detecting Gata4 in ELISA, IHC, WB. Suitable for Mouse.
Highlights
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| 种属反应性 | Human, Mouse, Rat | ||||||||
| 应用 | ELISA, IHC, WB | ||||||||
| 宿主 | Rabbit | ||||||||
| 克隆类型 | Polyclonal | ||||||||
| 同种型 | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Mouse GATA4 (Leu204-Ile314). | ||||||||
| 靶标 | Transcription factor GATA-4, GATA-binding factor 4, Gata4, Gata-4 | ||||||||
| 纯化方式 | Purified by antigen affinity column. | ||||||||
| Accession号 | Q08369 | ||||||||
| 状态 | Liquid | ||||||||
| 保存溶液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| 产品使用信息 |
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| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Transcription factor GATA-4 (GATA4) is a ~44 kDa protein. Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development. In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it down-regulates endocardial and endothelial gene expression. Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. Acts as a transcriptional activator of ANF in cooperation with NKX2-5. 1. Garry, GA. et al. (2021) Nature cell biology 23, 467-475. PMID: 33941892 2. Gonzalez-Teran, B. et al. (2022) Cell 185, 794-814.e30. PMID: 35182466 3. Lee, Y. et al. (1998) Molecular and cellular biology 18, 3120-9. PMID: 9584153 | ||||||||
| Note | For research use only. |

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