Anti-Mouse HSD11B2 Polyclonal Antibody (MX900014)

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概述
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参考文献
产品说明书

概述

货号

MX900014

品牌

abinScience

描述

Anti-Mouse HSD11B2 Polyclonal Antibody (MX900014) is a rabbit polyclonal antibody detecting Hsd11b2 in ELISA, IHC, WB. Suitable for Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Mouse, Rat

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Mouse HSD11B2 (Thr82-Ala331).

靶标

11-beta-hydroxysteroid dehydrogenase type 2, 11-DH2, 11-beta-HSD2, 1.1.1.-, Corticosteroid 11-beta-dehydrogenase isozyme 2, NAD-dependent 11-beta-hydroxysteroid dehydrogenase, Hsd11b2, Hsd11k

纯化方式

Purified by antigen affinity column.

Accession号

P51661

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2) is a ~42 kDa protein. Catalyzes the conversion of biologically active 11beta-hydroxyglucocorticoids (11beta-hydroxysteroid) such as corticosterone, to inactive 11-ketoglucocorticoids (11-oxosteroid) such as 11-dehydrocorticosterone, in the presence of NAD(+) (Probable). Functions as a dehydrogenase (oxidase), thereby decreasing the concentration of active glucocorticoids, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. Plays an important role in maintaining glucocorticoids balance during preimplantation and protects the fetus from excessive maternal corticosterone exposure. Catalyzes the oxidation of 11beta-hydroxytestosterone (11beta,17beta-dihydroxyandrost-4-ene-3-one) to 11-ketotestosterone (17beta-hydroxyandrost-4-ene-3,11-dione), a major bioactive androgen. Catalyzes the conversion of 11beta-hydroxyandrostenedione (11beta-hydroxyandrost-4-ene-3,17-dione) to 11-ketoandrostenedione (androst-4-ene-3,11,17-trione), which can be further metabolized to 11-ketotestosterone.

1. Meyer, A. et al. (2012) Toxicology 301, 72-8. PMID: 22796344

2. Beck, KR. et al. (2019) The Journal of steroid biochemistry and molecular biology 190, 19-28. PMID: 30902677

3. Cole, TJ. (1995) Endocrinology 136, 4693-6. PMID: 7664690

4. Zheng, HT. et al. (2020) The Journal of endocrinology 244, 177-187. PMID: 31600723

Note

For research use only.

图片

参考文献

产品说明书

Anti-Mouse HSD11B2 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Mouse HSD11B2 Polyclonal Antibody (MX900014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Mouse HSD11B2 Polyclonal Antibody (MX900014)

概述

图片

参考文献

产品说明书

相关产品推荐

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