Anti-Mouse IRF3 Polyclonal Antibody (MC458014)

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概述
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产品说明书

概述

货号

MC458014

品牌

abinScience

描述

Anti-Mouse IRF3 Polyclonal Antibody (MC458014) is a rabbit polyclonal antibody detecting Irf3 in ELISA, IHC, WB. Suitable for Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Mouse

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Mouse IRF3 (Gln195-Ile419).

靶标

Interferon regulatory factor 3, IRF-3, Irf3

纯化方式

Purified by antigen affinity column.

Accession号

P70671

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Interferon regulatory factor 3 (IRF3) is a ~46 kDa protein. Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes.

1. Honda, K. et al. (2005) Nature 434, 772-7. PMID: 15800576

2. Rao, Y. et al. (2025) Immunity 58, 74-89.e6. PMID: 39719712

3. Solis, M. et al. (2006) Biochemical pharmacology 72, 1469-76. PMID: 16846591

4. Honda, K. et al. (2006) Immunity 25, 349-60. PMID: 16979567

5. Savitsky, D. et al. (2010) Cancer immunology, immunotherapy : CII 59, 489-510. PMID: 20049431

Note

For research use only.

图片

参考文献

产品说明书

Anti-Mouse IRF3 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Mouse IRF3 Polyclonal Antibody (MC458014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Mouse IRF3 Polyclonal Antibody (MC458014)

概述

图片

参考文献

产品说明书

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