Anti-Mouse TREX1 Polyclonal Antibody (MV590014)

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概述

货号

MV590014

品牌

abinScience

描述

Anti-Mouse TREX1 Polyclonal Antibody (MV590014) is a rabbit polyclonal antibody detecting Trex1 in ELISA, IHC, WB. Suitable for Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Mouse

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Mouse TREX1 (Met11-Ala223).

靶标

Three-prime repair exonuclease 1, 3.1.11.2, 3'-5' exonuclease TREX1, Trex1

纯化方式

Purified by antigen affinity column.

Accession号

Q91XB0

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Three-prime repair exonuclease 1 (TREX1) is a ~33 kDa protein. Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements. Plays a key role in degradation of DNA fragments at cytosolic micronuclei arising from genome instability: its association with the endoplasmic reticulum membrane directs TREX1 to ruptured micronuclei, leading to micronuclear DNA degradation. Micronuclear DNA degradation is required to limit CGAS activation and subsequent inflammation.

1. Mazur, DJ. et al. (1999) The Journal of biological chemistry 274, 19655-60. PMID: 10391904

2. Mazur, DJ. et al. (2001) The Journal of biological chemistry 276, 17022-9. PMID: 11279105

3. Morita, M. et al. (2004) Molecular and cellular biology 24, 6719-27. PMID: 15254239

4. de Silva, U. et al. (2007) The Journal of biological chemistry 282, 10537-43. PMID: 17293595

5. Brucet, M. et al. (2007) The Journal of biological chemistry 282, 14547-57. PMID: 17355961

6. Brucet, M. et al. (2008) Protein science : a publication of the Protein Society 17, 2059-69. PMID: 18780819

7. Stetson, DB. et al. (2008) Cell 134, 587-98. PMID: 18724932

8. Pereira-Lopes, S. et al. (2013) Journal of immunology (Baltimore, Md. : 1950) 191, 6128-35. PMID: 24218451

Note

For research use only.

图片

参考文献

产品说明书

Anti-Mouse TREX1 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Mouse TREX1 Polyclonal Antibody (MV590014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Mouse TREX1 Polyclonal Antibody (MV590014)

概述

图片

参考文献

产品说明书

相关产品推荐

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