

| 货号 | VK776014 | ||||||||
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| 品牌 | abinScience | ||||||||
| 描述 |
Anti-ASFV pM1249L Polyclonal Antibody (VK776014) is a rabbit polyclonal antibody detecting pM1249L in ELISA, IHC, WB.
Highlights
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| 种属反应性 | African swine fever virus (ASFV) | ||||||||
| 应用 | ELISA, IHC, WB | ||||||||
| 宿主 | Rabbit | ||||||||
| 同种型 | IgG | ||||||||
| 克隆类型 | Polyclonal | ||||||||
| 免疫原 | E. coli - derived recombinant ASFV pM1249L (Gln346-Pro452). | ||||||||
| 靶标 | Minor capsid protein M1249L, pM1249L, Ba71V-060, M1249L | ||||||||
| 纯化方式 | Purified by antigen affinity column. | ||||||||
| Accession号 | Q65152 | ||||||||
| 状态 | Liquid | ||||||||
| 保存溶液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| 产品使用信息 |
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| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Minor capsid protein M1249L (pM1249L) is a ~144 kDa protein. Together with the penton and the other minor capsid proteins (p17, p49), forms a complicated network immediately below the outer capsid shell, stabilizing the whole capsid. In addition, blocks IFN-beta transactivation mediated by the cGAS-STING pathway and regulates the transcriptional activity of IFN-beta. Mechanistically, suppresses the phosphorylation of host key adapter protein TBK1 and degrades host IRF3 in the cytoplasm. 1. Wang, N. et al. (2019) Science (New York, N.Y.) 366, 640-644. PMID: 31624094 2. Cui, S. et al. (2022) Virus research 319, 198872. PMID: 35853521 | ||||||||
| Note | For research use only. |

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