Anti-HAdV-41 E1B-55K Polyclonal Antibody (VK466064)

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概述
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参考文献
产品说明书

概述

货号

VK466064

品牌

abinScience

描述

Anti-HAdV-41 E1B-55K Polyclonal Antibody (VK466064) is a rabbit polyclonal antibody detecting E1B-55K in ELISA, WB.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.

种属反应性

Human adenovirus E serotype 41 (HAdV-41)

应用

ELISA, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant HAdV-41 E1B-55K (Lys98-Asp472).

靶标

E1B 55 kDa protein, E1B-55K, E1B protein, large T-antigen, E1B-495R

纯化方式

Purified by antigen affinity column.

Accession号

P10546

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

E1B 55 kDa protein (E1B-55K) is a ~52 kDa protein. Plays a major role to prevent cellular inhibition of viral genome replication. Assembles an SCF-like E3 ubiquitin ligase complex based on the cellular proteins ELOB, ELOC, CUL5 and RBX1, in cooperation with viral E4orf6. This viral RING-type ligase ubiquitinates cellular substrates and targets them to proteasomal degradation: TP53/p53, LIG4, MRE11-RAD50-NBS1 (MRN) complex, ITGA3, DAXX and BLM. E1B-55K probably acts as the substrate-specific adapter of the SCF-like E3 ubiquitin ligase complex. Degradation of host TP53/p53 activity is essential for preventing E1A-induced TP53 accumulation that would otherwise lead to cell apoptosis and growth arrest.

Note

For research use only.

图片

参考文献

产品说明书

Anti-HAdV-41 E1B-55K Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-HAdV-41 E1B-55K Polyclonal Antibody (VK466064)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-HAdV-41 E1B-55K Polyclonal Antibody (VK466064)

概述

图片

参考文献

产品说明书

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