Anti-Human SMAD7 Polyclonal Antibody (HT350014)

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概述
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参考文献
产品说明书

概述

货号

HT350014

品牌

abinScience

描述

Anti-Human SMAD7 Polyclonal Antibody (HT350014) is a rabbit polyclonal antibody detecting Smad7 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Human, Mouse, Rat

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human SMAD7 (Met1-Arg426).

靶标

Mothers against decapentaplegic homolog 8, MADH8, SMAD family member 7, MADH7, SMAD 7, Mothers against decapentaplegic homolog 7, Smad7, hSMAD7, Mothers against DPP homolog 7, SMAD7, Mothers against DPP homolog 8, MAD homolog 8, MAD homolog 7

纯化方式

Purified by antigen affinity column.

Accession号

O15105

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

SMAD family member 7 (SMAD7) is a ~46 kDa protein. Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

1. Yan, X. et al. (2011) Molecular and cellular biology 31, 3700-9. PMID: 21791611

Note

For research use only.

图片

参考文献

产品说明书

Anti-Human SMAD7 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human SMAD7 Polyclonal Antibody (HT350014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human SMAD7 Polyclonal Antibody (HT350014)

概述

图片

参考文献

产品说明书

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