| 背景 | E3 ubiquitin-protein ligase NEDD4-like (NEDD4L/Nedd4-2) is a ~111 kDa protein. E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins and is thereby implicated in the regulation of various signaling pathways including autophagy, innate immunity or DNA repair. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Downregulates autophagy and cell growth by ubiquitinating and reducing cellular ULK1 or ASCT2 levels. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2. 1. Kamadurai, HB. et al. (2009) Molecular cell 36, 1095-102. PMID: 200644733. Gao, P. et al. (2021) Nature communications 12, 1194. PMID: 336085564. Kuratomi, G. et al. (2005) The Biochemical journal 386, 461-70. PMID: 154961415. Nazio, F. et al. (2017) Cell cycle (Georgetown, Tex.) 16, 1744-1747. PMID: 288203176. Kang, Y. et al. (2015) The Biochemical journal 472, 71-82. PMID: 263630037. Anta, B. et al. (2016) The Journal of biological chemistry 291, 19132-45. PMID: 274453388. Low, LH. et al. (2015) The Journal of biological chemistry 290, 7141-50. PMID: 256310469. Yoo, JC. et al. (2013) Journal of dermatological science 72, 246-51. PMID: 23999003 |
|---|
