Anti-Human SOCS1 Polyclonal Antibody (HT384014)

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50ug
100ug

数量：

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概述
图片
参考文献
产品说明书

概述

货号

HT384014

品牌

abinScience

描述

Anti-Human SOCS1 Polyclonal Antibody (HT384014) is a rabbit polyclonal antibody detecting SOCS1 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Human, Mouse, Rat

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human SOCS1 (Ser60-Ile211).

靶标

SOCS-1, SSI-1, JAB, JAK-binding protein, STAT-induced STAT inhibitor 1, Suppressor of cytokine signaling 1, Tec-interacting protein 3, TIP-3, SSI1, SOCS1, TIP3

纯化方式

Purified by antigen affinity column.

Accession号

O15524

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Suppressor of cytokine signaling 1 (SOCS1) is a ~23 kDa protein. Essential negative regulator of type I and type II interferon (IFN) signaling, as well as that of other cytokines, including IL2, IL4, IL6 and leukemia inhibitory factor (LIF). Downregulates cytokine signaling by inhibiting the JAK/STAT signaling pathway. Acts by binding to JAK proteins and to IFNGR1 and inhibiting their kinase activity. In vitro, suppresses Tec protein-tyrosine activity. Regulates IFN-gamma (IFNG)-mediated sensory neuron survival.

1. Thaventhiran, JED. et al. (2020) Nature 583, 90-95. PMID: 32499645

2. Hadjadj, J. et al. (2020) Nature communications 11, 5341. PMID: 33087723

3. Ohya, Ki. et al. (1997) The Journal of biological chemistry 272, 27178-82. PMID: 9341160

4. Kamizono, S. et al. (2001) The Journal of biological chemistry 276, 12530-8. PMID: 11278610

5. Frantsve, J. et al. (2001) Molecular and cellular biology 21, 3547-57. PMID: 11313480

Note

For research use only.

图片

Western blot

Western blot analysis was performed using anti-SOCS1 polyclonal antibody at 1ug/mL on various samples.
Lane 1: K562 cell lysate
Lane 2: Hepg2 cell lysate
Lane 3: A549 cell lysate
Lane 4: Mouse spleen lysate

参考文献

产品说明书

Anti-Human SOCS1 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human SOCS1 Polyclonal Antibody (HT384014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human SOCS1 Polyclonal Antibody (HT384014)

概述

图片

参考文献

产品说明书

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